Antibacterial activity in bovine lactoferrin-derived peptides

Antibacterial activity in bovine lactoferrin-derived peptides.

Several peptides sharing high sequence homology with lactoferricin B (Lf-cin B) were generated from bovine lactoferrin (Lf) with recombinant chymosin. Two peptides were copurified, one identical to Lf-cin B and another differing from Lf-cin B by the inclusion of a C-terminal alanine (lactoferricin). Two other peptides were copurified from chymosin-hydrolyzed Lf, one differing from Lf-cin B by t...

Mechanisms of the Antibacterial Activity of Lactoferrin and Lactoferrin-derived Peptides

Lactoferrin (Lf), a member of the transferrin family of iron-binding proteins, is now known to have a number of properties, including antibacterial activity towards a broad spectrum of Gram-negative and Gram-positive bacteria. The mechanism of the antibacterial activity of Lf is complex and involves beside iron-chelation, direct action on bacteria and/or the activation of the immune system. Lac...

Bovine Lactoferrin and Lactoferrin-Derived Peptides Inhibit the Growth of Vibrio cholerae and Other Vibrio species

Vibrio is a genus of Gram-negative bacteria, some of which can cause serious infectious diseases. Vibrio infections are associated with the consumption of contaminated food and classified in Vibrio cholera infections and non-cholera Vibrio infections. In the present study, we investigate whether bovine lactoferrin (bLF) and several synthetic peptides corresponding to bLF sequences, are able to ...

Antiviral Activity of Lactoferrin and Ovotransferrin Derived Peptides Towards Herpesviridae

Antibacterial activity of lactoferrin and a pepsin-derived lactoferrin peptide fragment.

Although the antimicrobial activity of lactoferrin has been well described, its mechanism of action has been poorly characterized. Recent work has indicated that in addition to binding iron, human lactoferrin damages the outer membrane of gram-negative bacteria. In this study, we determined whether bovine lactoferrin and a pepsin-derived bovine lactoferrin peptide (lactoferricin) fragment have ...